Dr. Barton F. Haynes will deliver this year’s James C. Hill Memorial Lecture, titled “The Path to HIV Vaccine Development,” on Thursday, Apr. 14, at 2 p.m. in Lipsett Amphitheater, Bldg. 10.
He will begin by discussing impediments to HIV vaccine
design and testing and recent progress to overcome
them. Then he will present new data on immune responses generated by the candidate vaccine tested in the RV144 HIV vaccine clinical trial in Thailand, the first HIV vaccine to demonstrate modest efficacy in humans. He will conclude by outlining the path of research to understand and build on the results of the Thai trial, which was sponsored by the U.S. Army and received major funding from NIAID.
Haynes is the Frederic M. Hanes professor of medicine and immunology at Duke University School of Medicine and director of both the Duke Human Vaccine Institute and the NIAID-funded Center for HIV/AIDS Vaccine Immunology.
A leader in the fields of human immune reconstitution and host-pathogen interactions,
Haynes co-developed a technique for growing human thymus tissue that can be transplanted into babies born without a thymus, thereby saving their lives.
In addition, Haynes changed the paradigm for understanding why HIV vaccine candidates have not yet elicited antibodies that stop a wide range of HIV strains from infecting human cells. He demonstrated that to interfere with the development
of powerful anti-HIV antibodies, the virus hijacks certain mechanisms used by the body to prevent autoimmune diseases. Thus, an effective strategy to develop an HIV vaccine must involve not only what a vaccine presents to the immune system, but also how the immune system regulates itself.
The annual Hill lecture is dedicated to the memory of the former NIAID deputy director, who helped build the institute’s HIV/AIDS research program during the earliest years of the epidemic and was instrumental in educating the public and government officials on the emerging threat of AIDS.