Six NIH extramural grantees have been awarded
the 2013 Nobel Prizes in physiology or medicine
and chemistry. Two will give lectures at NIH later
“For their discoveries of machinery regulating
vesicle traffic, a major transport system in our
cells,” said the Nobel Assembly at Karolinska
Institute, the Nobel Prize in Medicine 2013 has
been awarded jointly to James E. Rothman of Yale
University; Randy W. Schekman of the University
of California, Berkeley; and Thomas C. Südhof of
Stanford University School of Medicine.
Their work revealed how cells use small sacs,
called vesicles, to import and export materials to
and from cells. This transport system is a fundamental
process in how cells work.
“Without this wonderfully precise organization,”
said the Nobel Assembly, “the cell would lapse
NIH has supported Rothman’s work from 1978 to
2013 with more than $41.8 million in total funding
from 7 ICs: NIGMS, NIAMS, NIDDK, NCI,
NHGRI, NIMH and NINDS.
From 1979 to 2005, Schekman was awarded more
than $5.2 million in NIGMS funding support. He
is also affiliated with the Howard Hughes Medical
Südhof’s work garnered NIH support from 1969
to 2013 with over $15.6 million in grants from
NIMH, NINDS and NHLBI. He too is affiliated
with Howard Hughes Medical Institute.
The 2013 Nobel Prize in chemistry was awarded
jointly to NIH grantees Martin Karplus of Harvard
University, Michael Levitt of Stanford University
School of Medicine; and Arieh Warshel
of the University of Southern California for the
development of powerful multiscale computer
models used to understand and predict chemical
“The work of Karplus, Levitt and Warshel is
groundbreaking,” said the Royal Swedish Academy
of Sciences, “in that they managed to make
Newton’s classical physics work side-by-side
with the fundamentally different quantum
NIH began supporting Karplus in 1970 and
has provided more than $6.6 million in support
from NEI and NIGMS. Karplus, professor
of chemistry emeritus at Harvard University, is
also affiliated with the Université de Strasbourg
Since 1969, Levitt has received more than $25.8 million in support from NEI,
NIGMS, NIAMS and NIDDK. He will lecture at NIH on Nov. 18 at 4 p.m. in
Masur Auditorium, Bldg. 10, on the topic “The Birth and Future of Computational
Warshel received more than $11.4 million in support from 1976 to 2013 from
NEI, NIGMS and NCI. He will speak Nov. 20 at 1 p.m. in Masur on “Computer
Simulations of Biological Functions.”
NIH has granted a total of more than $108 million to the six scientists.
|Photo: Harold Shapiro/Yale
||Photo: L.A. Cicero
|Winning the 2013 Nobel Prize in physiology or medicine were NIH grantees (from l) Dr.
James E. Rothman, Dr. Randy W. Schekman and Dr. Thomas C. Südhof.
|Photo: Emmanuel Nguyen Ngoc
||Photo: L.A. Cicero
||Photo: Gus Ruelas/USC
|Winning the 2013 Nobel Prize in chemistry were NIH grantees (from l) Dr. Martin
Karplus, Dr. Michael Levitt and Dr. Arieh Warshel.