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Director's Pittman Lecture To Feature Lee Limbird

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Dr. Lee E. Limbird, professor of pharmacology and chair of the department of pharmacology at Vanderbilt University, will present the NIH Director's Margaret Pittman Lecture, on Wednesday, Sept.17 at 3 p.m. in Masur Auditorium, Bldg. 10. The title of her lecture is "Alpha2-Adrenergic Receptors Achieve Signaling Specificity via Coupling to Distinct Effectors and Targeting to Discrete Surface Domains."


Dr. Lee E. Limbird

Limbird's research evaluates the structure and function of alpha2-adrenergic receptors and the mechanisms by which they influence multiple physiological functions. Alpha2-adrenergic receptors are molecules on the cell surface that bind the hormones epinephrine or norepinephrine and evoke such physiological functions as the regulation of hormone and neurotransmitter release, platelet aggregation and secretion, vascular contractility, and smooth muscle tone.

Limbird and her colleagues are also examining the mechanisms by which alpha2-adrenergic receptors achieve their delivery to specialized domains on the surface of target cells.

Limbird earned an undergraduate degree in chemistry from the College of Wooster in Wooster, Ohio, in 1970. She received a Ph.D. in biochemistry from the University of North Carolina, Chapel Hill, in 1973.

Before moving to Vanderbilt, Limbird was a member of the departments of medicine and biochemistry at Duke University. From 1979 to 1985 she rose through the academic ranks at Vanderbilt, becoming professor of pharmacology in 1985 and chair of the department of pharmacology in 1991.

Limbird has published many original papers and reviews in scientific journals, and has received numerous awards and honors including an NIH Young Investigator Award in 1977, an NIH Research Career Development Award in 1979, and the John J. Abel Award in Pharmacology in 1987. From 1989 to 1991 she chaired the NIH pharmacology study section.

The lecture is part of the NIH Director's Wednesday Afternoon Lecture Series. All NIH employees are invited to attend. For more information, contact Hilda Madine, 4-5595.

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