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NASH Study Needs Volunteers

The NIDDK liver diseases section seeks male and female volunteers ages 18 and over for a research study to evaluate the effectiveness of pioglitazone, a new diabetes medicine, in treating people who have nonalcoholic steatohepatitis (NASH). NASH is a liver disorder with fat accumulation and inflammation, which may lead to liver scarring and cirrhosis. Medical history, physical examination, blood samples, chest X-ray, urinalysis, electrocardiogram, abdominal ultrasound and liver biopsy are required to assess eligibility for entry into the study. After NASH diagnosis is confirmed, volunteers will undergo more procedures. For more information, call Dr. Kittichai Promrat, 496-1665 or email kittichaip@intra.niddk.nih.gov.

Drug Treatment for INCL

Help doctors at NIH determine if a drug called Cystagon can be an effective treatment for INCL — infantile neuronal ceroid lipofuscinosis. For more information call 1-800-411-1222 or 1-866-1010 (TTY).

Healthy Overweight Women Needed

The Uniformed Services University weight management program is looking for healthy nonsmoking overweight women ages 18-55 to participate in a weight management program as part of an ongoing study examining factors affecting weight loss. In addition, applicants should not be pregnant, have problems with thyroid, kidney or heart disease, diabetes or uncontrolled hypertension. Program and materials are provided free. If interested call (301) 295-9664.

Cognitive Neurosciences Studies

NIH invites volunteers to participate in a variety of neuropsychological tests, brain imaging studies and related neurological evaluations. You must be ages 6 to 80 and diagnosed with either CBD; frontotemporal dementia; Pick's disease; progressive aphasia; Urbach-Wiethe (lipoid proteinosis) or focal frontal lesions due to first stroke, first penetrating head injury or first excised tumor. Call 1-800-411-1222 for more information.

Postpartum Depression Study

The Behavioral Endocrinology Branch, NIMH, is seeking volunteer mothers ages 18-40 who have had one or more past episodes of postpartum depression following a full-term pregnancy, but are not currently depressed. Participants must be free of medical illnesses, medication-free and currently not breastfeeding. Volunteers may be asked to participate in a 6-month protocol investigating the effects of hormones on brain and behavior. All participants who complete the study will be paid. For more information call Linda Simpson-St. Clair, 496-9576.

Heart Disease Study Seeks African Americans

The Heart Disease Risk Factors in African Americans Study is investigating the relationship of obesity to heart disease risk factors in healthy, nondiabetic African American men and premenopausal women ages 18-50. Currently being enrolled are African American men who weigh 180 lbs. or more, and African American women who weigh 150 lbs. or more. There will be a series of four outpatient visits to the Clinical Center in which participants will have body fat analyses, an electrocardiogram, and other tests. If interested, call 402-7119 for more information. All subjects will be paid.


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