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Harvard's Livingston To Give Khoury Lecture

The past quarter century has seen a tremendous increase in scientists' understanding of cell growth. During that time researchers have learned that a cell's life cycle and functions are controlled through complex interactions of DNA, proteins and other molecules. As each molecule moves within or between cells, it communicates with other structures in a coordinated dance to determine a cell's fate. The secret for scientists, therefore, has been finding and understanding each of those molecular interactions.

Dr. David Livingston

On Wednesday, Nov. 28, a leading scientist who has revealed many such interactions during 35 years of research will visit the NIH campus. On that date, Harvard University's Dr. David Livingston will present "Molecular and Biological Analyses of BRCA1 Function" during the annual George Khoury Lecture to be held at 3 p.m. in Masur Auditorium, Bldg. 10. Livingston will discuss the role of BRCA1, a tumor suppressor protein that plays a pivotal role in controlling cell growth and a contributing factor to most cases of familial breast and ovarian cancer.

Throughout his career, Livingston has studied the biochemical processes that cause cells to break from their carefully controlled life cycles to grow out of control and cause cancer. His laboratory conducted key experiments that showed how the retinoblastoma gene regulates cell division, a seminal discovery in cancer research. That discovery led to increased basic research in the molecular biology of cancer, resulting in many new discoveries from his and other laboratories.

Livingston is a past staff member of the National Cancer Institute and has been at the Dana-Farber Cancer Institute and Harvard University since 1973. He is currently deputy director of the Dana-Farber/Harvard Cancer Center, chief of the Charles A. Dana Division of Human Cancer and Genetics at Dana-Farber Cancer Institute, and the Emil Frei professor of genetics and medicine at Harvard.

A member of the National Academy of Sciences and the Institute of Medicine, he has received numerous awards throughout his distinguished career. Among these are the Dana-Farber Claire W. and Richard P. Morse Research Award, the Brinker International Award for Breast Cancer Research, the Lila Gruber Cancer Research Award, and the Association of American Medical Colleges Award for Distinguished Research in the Biomedical Sciences.

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