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Wednesday Afternoon Lectures

The Wednesday Afternoon Lecture series — held on its namesake day at 3 p.m. in Masur Auditorium, Bldg. 10 — features Dr. Nicholas R. Cozzarelli on Dec. 5; he will speak on "Mechanisms of DNA Unlinking and Chromosome Segregation." He is professor, department of molecular and cell biology, University of California, Berkeley.

On Dec. 12, Dr. Wilma K. Olson will discuss "DNA Mechanics and Gene Regulation." She is Mary I. Bunting professor of chemistry and director, Center for Molecular Biophysics and Biophysical Chemistry, Rutgers University.

For more information or for reasonable accommodation, call Hilda Madine, 594-5595.

Forum on Fitness in Workplace, Dec. 7

The staff training in extramural programs (STEP) committee will hold a Workplace Strategies Forum on Friday, Dec. 7 from 1 to 4 p.m. in Bldg. 1, Wilson Hall. Its theme is "Staying Healthy at the National Institutes of (Everyone Else's) Health."

Let's face it, extramural jobs are desk jobs, so you may not get up and walk around as often as you would like, or should. And since you spend so much time at the desk, eyestrain and repetitive stress injury are likely if ergonomics are ignored. And the last challenge: how do you eat right when junky temptations abound? The session will feature short talks and question-and-answer sessions with an expert on "fitness in the office," an ergonomics consultant and a nutritionist.

FAES Announces Spring Courses

The FAES Graduate School at NIH announces the schedule of courses for the spring semester. The evening classes sponsored by the Foundation for Advanced Education in the Sciences will be given on the NIH campus.

Courses are offered in biochemistry, biology, biotechnology (daytime courses), chemistry, immunology, languages, medicine, microbiology, pharmacology, psychiatry, statistics, toxicology, administration and courses of general interest.

It is often possible to transfer credits earned to other institutions for degree work, and many courses are approved for category 1 credit toward the AMA Physician's Recognition Award.

Classes will begin Jan. 28; mail registration ends Dec. 28 and walk-in registration will be held Jan. 9-15. Tuition is $100 per credit hour, and courses may be taken for credit or audit. Courses that qualify for institute support as training should be cleared with supervisors and administrative officers as soon as possible. Both the vendor's copy of the training form and the FAES registration form must be submitted at the time of registration. Note that FAES cannot access training forms entered in the NIHTS system; a signed hard copy (vendors' copy of SF182 form) is needed in order to process registrations for classes.

Spring schedules will be available in the graduate school office in Bldg. 60, Suite 230, the foundation bookstore in Bldg. 10, Rm. B1L101, and the business office in Bldg. 10, Rm. B1C18. To have a schedule sent, call 496-7976 or visit

Mouse Model Created for Dental Defect

Scientists at the National Institute of Dental and Craniofacial Research have created an animal model for amelogenesis imperfecta, a dental defect that results in abnormally formed tooth enamel. The model will allow scientists to study how the disorder develops as well as to clarify the enamel-forming process.

Dr. Ashok Kulkarni and colleagues genetically engineered mice by deleting, or knocking out, the gene responsible for producing amelogenin, the most abundant protein in enamel. As early as two weeks of age, the knockout mice had teeth with chalky white discoloration and an abnormally thin layer of enamel. Detailed evaluation revealed that the enamel structure was atypical. The scientists published their findings in the Journal of Biological Chemistry.

"This is the first animal model in which a tooth-specific gene has been knocked out," said the study's lead author Kulkarni, from the NIDCR functional genomics unit and gene targeting facility. "We think the mouse model will be useful for studying the functions of amelogenin in enamel formation as well as for developing therapies for amelogenesis imperfecta."

Amelogenesis imperfecta occurs in approximately 1 in 14,000 individuals in the U.S. It results in malformed, thin enamel that may render teeth susceptible to damage and decay. Dental enamel is the outermost layer of the teeth and is the hardest substance in the body. It is composed of a protein framework — made up mostly of amelogenin — on which minerals such as calcium are deposited.

Messiah Sing-Along Set, Dec. 2

The fifth annual Messiah Sing-Along will take place on Sunday, Dec. 2 at 3 p.m. at Richard Montgomery High School in Rockville. Presented by the NIH Community Orchestra and the Bethesda Little Theatre, the event will feature the orchestra along with a chorus and soloists. Come prepared to sing your part or just listen and enjoy the music.

Tickets are available at the door and are $10 for adults and $5 for seniors. Children 12 and under are admitted free. As in past years, the concert will benefit NIH charities. For more information, visit or contact Gary Daum at (301) 897-8184 or

CRIS Education Sessions Offered

The implementation of a clinical research information system (CRIS) at the Clinical Center will affect the work lives of intramural staff involved in patient care and biomedical research. The following sessions are targeted for all interested persons including physicians, nurses, technicians and IT specialists who work with the current medical information system (MIS). The sessions will present real-life examples of similar system installations. Sessions will be presented from 1:30 to 3 p.m. in Lipsett Amphitheater, Bldg. 10.

Monday, Dec. 3 – Managing Data for Clinical Care Delivery and Research: How to Get More Bang for Your Buck! Topics include Research & Clinical Database, Privacy & Security, Standards & Terminologies

Monday, Jan. 7 – Process Improvements and Organizational Changes: Technology as Push or Pull? Topics include Leading Change, Case Study-Reductions of Medical Errors

Thursday, Feb. 7 – System Implementation: Lessons Learned But Not Forgotten. Topics include Clinician Acceptance & Changing Clinical Practice, Implementation – The Good, The Bad & The Ugly

Monday, Mar. 11 – System Benefits: Technology Value – What's in It for Me? Topics include Incentives, Risks & Benefits, Clinical & Process Outcomes

CME credit available. For reasonable accommodation, call the CC department of clinical research informatics, 594-DCRI.

WFLC's 'Phases' Series Tackles Stress During the Holiday Season

The Work and Family Life Center's "Faces and Phases of Life" seminar series continues with sessions on how to manage stress. Preregister for any session by calling the WFLC, 435-1619. For more information, visit the web site at Sign-language interpretation is provided, unless otherwise indicated.

December features Keeping Yourself Together: A 3-Part Stress Management Series presented by the Employee Assistance Program.

Part 1: Stress Awareness – Wednesday, Dec. 5, 1-2 p.m., Wilson Hall, Bldg. 1;

Part 2: The Negative Impact of Stress, or "I'm Not Stressed Out!" Tuesday, Dec. 11, 1-2 p.m., Wilson Hall, Bldg. 1;

Part 3: Developing Your Personal Stress Management Plan, Wednesday, Dec. 19, 1-2 p.m., Bldg. 31, Rm. 6C10.

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