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Vol. LVIII, No. 5
March 10, 2006

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NIAID Announces Five Appointments

NIAID recently announced the appointment of five individuals to senior management positions within the institute.

Dr. Hugh Auchincloss, Jr.  

Dr. Hugh Auchincloss, Jr., has been named new principal deputy director of NIAID. He will serve as second in command to NIAID director Dr. Anthony Fauci and will have broad responsibilities for carrying out the institute's programs. Auchincloss joins NIAID from Massachusetts General Hospital, where, as professor of surgery at Harvard Medical School, he earned an international reputation in the field of organ transplantation. An immunologist, Auchincloss is the founder and director of the Juvenile Diabetes Research Foundation Center for Islet Transplantation at Harvard Medical School. He has spent much of his time in recent years as chief operating officer of NIAID's Immune Tolerance Network. He also serves as chairman of the FDA's subcommittee on xenotransplantation. He was elected president of the American Society of Transplantation in 2005.

  Dr. H. Clifford Lane

Dr. H. Clifford Lane has been appointed deputy director for clinical research and special projects. Previously he served as NIAID's acting principal deputy. Lane will continue to serve as director of the newly established Division of Clinical Research. In his new position, he will also function as a liaison with the Departments of Defense and Homeland Security and other outside constituents.

Dr. John J. McGowan  

Dr. John J. McGowan has been appointed to the new position of deputy director for science management. He will have overall responsibility for directing NIAID's business and administrative requirements as well as its science planning, policy and integration. A virologist by training, McGowan has served in multiple roles at NIAID including chief of the Developmental Therapeutics Branch and associate director for the Basic Research and Development Program, both within the institute's Division of AIDS. Most recently, he served as director of the Division of Extramural Activities, a position he held since 1991, and as acting NIAID associate director for management and operations since December 2004.

  Dr. Kathryn Zoon

Dr. Kathryn Zoon has been appointed director of the Division of Intramural Research, replacing Dr. Thomas Kindt. Since June 2005, following Kindt's retirement, she has served as acting director of DIR and, since June 2004, she was deputy director for planning and development at DIR. Previously, she was the principal deputy director of the Center for Cancer Research at the National Cancer Institute, and prior to that she was director of the Center for Biologics Evaluation and Research at FDA.

Zoon is an associate editor of the Journal of Interferon Research and serves on the board of directors of the Foundation for Advanced Education in the Sciences. The recipient of numerous awards, she was elected to the Institute of Medicine in 2002.

Gregory Folkers  

Gregory Folkers has been appointed chief of staff to Fauci, leading the newly created Immediate Office of the Director. Folkers came to NIAID in 1991 after being employed in various writing and communications positions in the Boston area. After working as a science writer and editor in the NIAID Office of Communications, he has for the past decade worked directly with Fauci as a special assistant and senior public affairs advisor.

NIDCR Mourns Former Director Kreshover

Dr. Seymour J. Kreshover, 93, former director of NIDR (now NIDCR) died Jan. 23 at his home in Winter Park, Fla. A dentist, physician and researcher, he is remembered for broadening dental research and linking it to the biomedical sciences and medicine. He headed NIDR from 1966 to 1975.

"Dr. Kreshover was an outstanding leader, a dedicated public servant and an extraordinary scientist who made numerous contributions to dental and oral health research," said NIDCR director Dr. Lawrence Tabak. "He was also a friendly and thoughtful man who was liked and respected at the institute and by the wider research community. It was a joy to see him each year at the NIDCR lecture named in his honor."

Dr. Seymour J. Kreshover  

Kreshover's efforts to connect dentistry to the biomedical sciences led him to expand the institute's research areas and to encourage basic research throughout the programs. He created laboratories on neurobiology and developmental biology whose research laid the foundation for future discoveries on pain and on normal and abnormal craniofacial development. His goal of broadening dental science also gave rise to a new program of dental research centers in universities. The centers attracted scientists from disciplines not traditionally associated with dentistry and provided a venue for training researchers.

During his tenure, Kreshover also established a national program aimed at reducing the incidence of dental caries. Basic and applied research from the National Caries Program resulted in an enhanced understanding of the dental caries process, better dental sealants and the promotion of fluoride applications through school-based mouth rinse programs.

A native of New York City, Kreshover earned a B.A. from New York University in 1934. In 1938, he received a D.D.S. from the University of Pennsylvania School of Dentistry and then in 1942 received a Ph.D. in clinical medicine and pathology from Yale University. He also went on to earn an M.D. from NYU School of Medicine in 1949.

After receiving his M.D., Kreshover joined the Medical College of Virginia where he served as a professor and clinician in the department of oral pathology, director of dental research and director of postgraduate and graduate studies.

He arrived at NIDR in 1956 and initially headed the institute's Intramural Research Program. In 1966, he was named director. A member of the Public Health Service Commissioned Corps, he assumed the rank of assistant surgeon general when he rose to the director post.

Kreshover was the recipient of numerous honors and awards, including the Department of Health, Education and Welfare Distinguished Service Medal; the PHS Meritorious Service Award, the Pierre Fauchard Medal, the Henry Spenadel Award and the Alfred C. Fones Memorial Award. He had several honorary degrees and also held membership in a number of medical and dental associations. In 1983, NIDR established the annual Kreshover Lecture Series in his honor.

When not working, Kreshover enjoyed spending time with his family. He could also be found sailing as well as collecting and showing classic cars, including such vintage models as a 1953 MG-TD, Jaguar XKE and Jaguar 120. In addition, he was a skilled woodworker who had taken woodworking classes and also maintained a workshop devoted to the hobby.

He is survived by his wife of 59 years, Jacqueline Kreshover of Winter Park; four children, Karen Davis of Gaithersburg, Douglas Kreshover of Vienna, Janis Kasch of Ormond Beach, Fla., and Lauren Watkins of Windermere, Fla.; 13 grandchildren; and three great-grandchildren.

NINDS's Nelson Retires With 35 Years of Federal Service

Dr. Karin Nelson, acting chief of the NINDS Neuroepidemiology Branch, retired Jan. 3 with 35 years of federal service, all with NINDS. "It's truly been a privilege to work at NIH," she said. Nelson earned her undergraduate degree from the University of Minnesota and her medical degree from the University of Chicago School of Medicine in 1957. She then trained in neurology at the University of Maryland, George Washington University and the National Hospital, Queen Square, London.

  Dr. Karin Nelson

She first came to NIH in 1964 as a medical officer in the Perinatal Research Branch, working on NINDS's National Collaborative Perinatal Project (NCPP). The project was a large multicenter prospective study of factors related to developmental disability with such disorders as cerebral palsy, epilepsy and mental retardation. The study followed 50,000 women throughout their pregnancies and their children through age 8.

"I came to NIH because there was great controversy about what to do about febrile seizures. It was the question I was asked about most often by parents and colleagues, at lunch and in the parking lot," said Nelson. Febrile seizures are convulsions brought on by a fever in infants or small children. "As febrile seizures are among the most common disorders in child neurology, it seemed that there ought to be answers. And the NCPP at NINDS had data that would make it possible to get some evidence-based answers. The results of that research contributed to changes in medical practice with regard to this common disorder," she said.

In 1967 Nelson left NIH to become a neurology instructor at George Washington University and an associate neurologist at Children's Hospital in Washington, D.C. She returned to NIH in 1973 as a medical officer in the Neuroepidemiology Branch, NINDS. Later she became acting chief of the branch, the position she held at retirement. In addition to her NINDS responsibilities, Nelson continued to serve as professor of neurology at GW.

During her tenure at NINDS, she studied the natural history and etiology of major childhood neurological problems — focusing on cerebral palsy, epilepsy, neonatal seizures, febrile seizures and the neurological outcome in multiple births. Her work often led to collaborations with researchers across the country and worldwide including the California state department of health and the University of Adelaide in Australia.

Nelson has authored or coauthored numerous articles, reviews and book chapters that together constitute a major part of current scientific knowledge about child neurology.

Not surprisingly, her research has garnered her many awards including the Bernard Sachs and Hower Awards from the Child Neurology Society, the Distinguished Basic Neuroscientist Epilepsy Research Award from the American Epilepsy Society and the Milken Family Medical Foundation, and NIH Director's and Merit Awards.

In retirement, Nelson plans to work part-time at Children's National Medical Center.

Four Join NIAID Advisory Council

Four new members recently joined the National Advisory Allergy and Infectious Diseases Council for 4-year terms. They are: Dr. Barbara A. Baird of Cornell University; Dr. Kathryn M. Edwards of Vanderbilt University; Dr. Martin Rosenberg of Promega Corp. in Madison, Wisc.; and Dr. Megan Sykes of Harvard Medical School.

NIAID director Dr. Anthony Fauci (r) welcomes four new members to his council. They are (from l) Dr. Megan Sykes, Dr. Martin Rosenberg, Dr. Barbara Baird and Dr. Kathryn Edwards.  

Baird is a professor in the department of chemistry and chemical biology at Cornell. She also serves as director of the Nanobiotechnology Center and is principal investigator for Cornell's training grant in molecular biophysics.

Edwards is professor of pediatrics at Vanderbilt. She was principal investigator of the NIAID-funded, placebo-controlled influenza efficacy trial comparing live, attenuated and inactivated influenza vaccines in more than 3,000 volunteers and now leads the NIAID-supported vaccine and treatment evaluation unit at Vanderbilt.

Rosenberg is chief scientific officer of Promega and is an adjunct professor in the department of bacteriology at the University of Wisconsin and in the department of biochemistry at the Robert Wood Johnson Medical School.

Sykes is the Harold and Ellen Danser professor in the department of surgery and a professor of medicine at Harvard Medical School. She is an immunologist and associate director of the Transplantation Biology Research Center at Massachusetts General Hospital.

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