|Dr. Lawrence Corey
At NIAID’s fourth annual Stephen E. Straus Memorial Lecture
on Infectious Diseases, Seattle-based researcher Dr. Lawrence Corey will describe research that is changing conventional
wisdom about herpes simplex virus (HSV) infection. “Life Below the Belt and the Pathogenesis of HSV Infection: The Politics Are Mucosal,” will be presented on Thursday, Sept. 22, at 3 p.m. in Bldg. 40, Rm. 1201/1203.
For more than 50 years, most scientists have believed that HSV type 2, which causes genital
herpes and severe herpesvirus infections in newborns and people with compromised immune systems, established itself in sacral nerve root ganglia located at the base of the spine and that reactivation of latent infection was determined largely by processes inside the infected nerves. It was also generally accepted
that reactivation, while rare, invariably led to sores in genital tissues. Corey will describe research that is causing experts to revise previous
models of HSV-2 reactivation.
For example, recent data suggest that infected people shed HSV-2 nearly daily but experience no clinical symptoms. Moreover, a pronounced role for immune cells in the genital mucosa is beginning to be discerned. Data modeling suggests
that because of this mucosal immunity, less than 15 percent of HSV-2 reactivations result in genital ulcers. This emerging picture gives reason for optimism that immunological
approaches to genital herpes therapy are within reach.
Corey is president and director of the Fred Hutchinson Cancer Research Center and professor
of medicine and laboratory medicine at the University of Washington. An expert in virology
and vaccine development, his research is focused on herpes viruses, HIV and other viral infections, including those associated with cancer.
Corey is also principal investigator for the NIAID-sponsored HIV Vaccine Trials Network.
The lecture series honors Dr. Stephen Straus, who served NIAID for 30 years as a lab chief and senior investigator, continuing in the latter role after his appointment as the first director of NCCAM.—Anne A. Oplinger