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NIH Record  
Vol. LXVI, No. 3
  January 31, 2014
Geroscience Summit Examines Intersection of Aging, Chronic Disease
Obama Honors Outstanding Early Career NIH Scientists
NIH Addresses Gender Issues in Research On International Stage
Kidney Cancer Genes Identified Through Trans-NIH Effort
NINR Launches Innovative Questions Initiative
Blood Test Identifies Early Pancreatic Cancer
NIAMS Launches ‘Year of Health’ with 2014 Multicultural Planners
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‘Father of Computational Enzymology’
Nobelist Warshel Visits NIH Ahead of Stockholm

2013 Nobel laureate Dr. Arieh Warshel
2013 Nobel laureate Dr. Arieh Warshel
How do complex chemical systems in the body work? We can answer this question, see simulations of the answer and even possibly visualize what sometimes goes awry—largely because of work done by 2013 Nobelist Dr. Arieh Warshel, who spent the last 45+ years disproving an idea he had as an undergrad.

“So the overall issue is, how do you model biological functions?” he said, showing an unpublished scientific manuscript he wrote in 1965. “I have been interested in enzymes since my undergraduate work in the Technion [Israel], where I looked at the effect of ionic strengths on the speed of chymotrypsin and concluded that electrostatic [force] is not important, which of course is wrong.”

Can Chinese Herbs Treat Cancer Pain?
NCI Collaborates with Beijing Clinician-Scientist

When Dr. Zhizheng Zhao left Beijing to do research at NCI-Frederick, he brought 5 years of experience as a physician and scientist in the oncology department of Guang’anmen Hospital, one of the largest integrative medicine hospitals in China.

“I was quite interested in oncology,” he says, “because this will really benefit more patients.”

Zhao trained and practiced in Beijing, where air pollution is several times above WHO’s recommended health threshold. More people die from lung cancer each year in China than from any other type of cancer.

“China has sacrificed the environment for economic growth,” Zhao says. “So we need a lot of methods to deal with diseases associated with environmental change.” These include chemotherapy, immunotherapy, surgery and TCM (traditional Chinese medicine). Successfully using TCM requires learning the theory behind it in order to correctly combine Western and Eastern therapies for optimum benefit to the cancer patient.