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Vol. LXVI, No. 10
May 9, 2014
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Former NIAID Scientist To Give Chanock Lecture, May 27

Dr. Raphael Dolin

Dr. Raphael Dolin, the Maxwell Finland professor of medicine and of microbiology and molecular genetics at Harvard Medical School and Beth Israel Deaconess Medical Center, will present the annual NIAID Robert M. Chanock Memorial Lecture. His talk, titled “Approaches to HIV Vaccine Development,” will take place on Tuesday, May 27, at 9 a.m., in the Bldg. 50 1st floor conference room. The lecture honors Chanock, who served as chief of NIAID’s Laboratory of Infectious Diseases for more than three decades.

Dolin will discuss future directions in HIV vaccine research. Clinical trials of HIV vaccines over the last 30 years have faced a number of challenges, including the apparent absence of a model of naturally acquired immunity to HIV, the limitations of experimental animal models and the complexity and cost of the trials themselves.

During this time, substantial progress has been made toward novel candidate HIV vaccines, including the development of adenovirus and orthopox vectors and “mosaic” gene inserts designed to improve the immune system’s recognition of HIV. Particularly noteworthy has been the identification of highly potent, broadly neutralizing antibodies against HIV. Dolin will talk about using clinical studies to better understand how these antibodies could prevent or treat HIV infection.

A graduate of Harvard College and Harvard Medical School, Dolin trained at NIAID’s Laboratory of Infectious Diseases and led the medical virology section of NIAID’s Laboratory of Clinical Investigation. He has authored more than 200 articles, books, chapters and reviews. He has directed the Harvard Medical School HIV vaccines clinical trials unit and currently is a co-editor of Principles and Practice of Infectious Diseases, a leading textbook in the field of infectious diseases.

Dolin is a fellow of the American College of Physicians, the Infectious Diseases Society of America and chair of the board of scientific counselors for NIAID’s Vaccine Research Center.


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