Dr. Y. Peng Loh, chief of NICHD’s section on cellular neurobiology, will give the fall seminar in the Anita B. Roberts Lecture Series: Distinguished Women Scientists at NIH. Her talk, “Neurotrophic Factor a1: A Key Regulator of Neuroprotection, Depression and Cancer Metastasis,” will be held on Thursday, Dec. 11 at 3:30 p.m. in Lipsett Amphitheater, Bldg 10. The series is sponsored by the NIH women scientist advisors committee and Office of Research on Women’s Health and highlights outstanding research achievements of women scientists at NIH.
Loh is internationally recognized for her contributions toward understanding the mechanisms underlying the enzymatic processing, intracellular trafficking and sorting of pro-hormones and neuropeptides to secretory granules of the regulated secretory pathway. She revolutionized the field by discovering many non-enzymatic roles of the pro-hormone processing enzyme carboxypeptidase E (CPE). Recently, she identified secreted CPE (now named neurotrophic factor a1) as a new signaling molecule with important neurotrophic functions in mediating neuroprotection, preventing stress-induced depression and in neural stem cell differentiation in the developing brain. Additionally she has discovered a splice variant form of CPE (CPE-DN) that induces metastasis in cancer cells and is a powerful biomarker for predicting future metastasis in cancer patients. Loh’s pioneering work has led to more than 200 publications and, together with her mentoring service to the NIH community, has earned her numerous awards including the FASEB Excellence in Science Award, the Public Health Service Superior Service Award, Women in Endocrinology Mentor’s Award for Outstanding Research and Mentoring and the NIH Director’s Award for Mentoring.
The seminar series is dedicated to the memory of Anita B. Roberts, chief of NCI’s Laboratory of Cell Regulation and Carcinogenesis from 1995 to 2006, honoring her role as an exceptional mentor and scientist. Prior to her death in May 2006, she spent 30 years at NIH performing pioneering work on transforming growth factor beta and its role in wound healing, carcinogenesis and autoimmune disease.
The lecture is open to all and will be followed by a question-and-answer session. Sign language interpreters will be provided upon request. Those who need reasonable accommodation should contact Margaret McBurney at (301) 496-1921 and/or the Federal Relay (1-800-877-8339) 5 days before the lecture.