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Vol. LXVII, No. 9
April 24, 2015

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Volunteers

Hard-to-Treat Depressive Symptoms?

This inpatient research study is assessing the effectiveness of the oral medication diazoxide (an enhancer of glutamate transporter function) versus placebo to rapidly improve hard-to-treat major depressive symptoms. The study enrolls participants ages 18-65, who are diagnosed with major depressive disorder, have previously failed to respond to treatment and are free of other serious medical conditions. The study can last up to 12 weeks and is conducted at the Clinical Center. There is no cost to participate. We enroll eligible participants locally and from around the country. Travel arrangements are provided and costs are covered by NIMH (arrangements vary by distance). After completing the study, participants receive short-term follow-up care at NIH while transitioning back to a provider. For more information visit www.nimh.nih.gov/JoinAStudy, call 1-877-MIND-NIH (1-877-646-3644), TTY 1-866-411-1010 or email moodresearch@mail.nih.gov. See study 14-M-0041.

What Does a Depressed Person’s Brain Look Like?

The purpose of this brain imaging study is to see if individuals, ages 18 and older, with major depressive disorder have increased inflammation in their brain. The study involves four outpatient visits or a brief inpatient stay at the Clinical Center. Procedures include blood tests, medical evaluations and two brain scans (PET and MRI). Participants do not need to stop their current medications. Those not eligible to participate include pregnant women, current smokers and individuals with serious medical conditions. There is no cost to participate. We enroll eligible participants locally and from around the country. Travel arrangements are provided and costs are covered by NIMH (arrangements vary by distance). After completing the study, participants receive short-term follow-up care at NIH while transitioning back to a provider. For more information visit www.nimh.nih.gov/JoinAStudy, call 1-877-MIND-NIH (1-877-646-3644), TTY 1-866-411-1010, or email moodresearch@mail.nih.gov. See study 13-M-0100.

Improve Depressive Symptoms Faster?

Studies are enrolling eligible participants ages 18-65 with unipolar or bipolar depression symptoms for a 2-3 month inpatient stay. The study compares ketamine, an experimental medication, to placebo and evaluates rapid reduction of depressive symptoms (within hours). For more information and eligibility criteria go to www.nimh.nih.gov/JoinAStudy, call 1-877-MIND-NIH (1-877-646-3644) TTY 1-866-411-1010 or email moodresearch@mail.nih.gov. See study 04-M-0222.

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