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Vol. LXVII, No. 12
June 5, 2015


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Hard-to-Treat Depressive Symptoms?

This inpatient research study is assessing the effectiveness of the oral medication diazoxide (an enhancer of glutamate transporter function) versus placebo to rapidly improve hard-to-treat major depressive symptoms. The study enrolls eligible participants ages 18-65, who are diagnosed with major depressive disorder, have previously failed to respond to treatment and are free of other serious medical conditions. The study can last up to 12 weeks and is conducted at the Clinical Center. There is no cost to participate. For more information, visit, call 1-877-646-3644 (TTY 1-866-411-1010) or email Refer to study 14-M-0041.

Improve Depressive Symptoms Faster?

Studies are enrolling eligible participants ages 18-65 with unipolar or bipolar depression symptoms for a 2-3 month inpatient stay. The study compares ketamine, an experimental medication, to placebo and evaluates rapid reduction of depressive symptoms (within hours). For more information and eligibility criteria go to, call 1-877- 646-3644 (TTY 1-866-411-1010) or email See study 04-M-0222.

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