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The Brain’s Internal Clock Continually Takes Its Temperature

Young woman reaching out with both hands for alarm clock.

Circuits in the brain act as an internal clock that tells us it’s time to sleep, controls how long we stay asleep and, according to a new study, constantly monitors changes in external temperature and integrates that information into the neural network.

Photo: knape/iStock

Circuits in the brain act as an internal clock to tell us it is time to sleep and to control how long we then stay asleep. A new study in flies suggests that a part of that clock constantly monitors changes in external temperature and integrates that information into the neural network controlling sleep. The NINDS-supported study was published in Nature.

“This study takes advantage of the powerful model system of the fly’s circadian clock network to demonstrate how temperature cues from the environment are used to control the time and duration of sleep,” said Dr. Janet He, program director, NINDS.

The circadian clock is a fundamental process found in nearly every living organism that coordinates sleep behavior with changes in the environment. The link between the light/dark cycle and the onset of sleep is well recognized; however, changes in temperature also appear to affect sleep patterns in humans.

“The clock discovered in flies more than 30 years ago is essentially the same one found in the human brain,” said Dr. Orie Shafer, associate professor at the University of Michigan and senior author of this study. “Circadian clock studies are beautiful examples of how the fly has important things to tell us about how our bodies work.”

By using a special fluorescent protein that changes from green to red when neurons fire, Shafer and his team watched the activity of different parts of the fly brain’s circadian clock while they increased or decreased the surrounding temperature. To their surprise, an area in the fly brain’s circadian clock called the DN1p increased its activity when cooled and became less active when heated.

As experienced by anyone who has traveled across time zones, the circadian clock can be “reset” over time in response to new day/light cycles. The clock of flies can be retrained to new cycles of either light or temperature, so Shafer and his colleagues next looked at whether DN1p is involved in resetting the clock to a new heating/cooling cycle.

Because DN1p neurons are thought to be sleep-promoting, the researchers blocked their activity or eliminated them genetically. Both affected the flies’ ability to retrain their sleep cycle in response to changes in temperature, highlighting the importance of DN1p for control of sleep behavior.

The circadian clock of larger animals and humans is also sensitive to changes in temperature, and because of their larger size, would require input from external sensory organs. The fact that, despite its small size, the fly clock also relies on temperature sensors outside the brain suggests that the findings of this study could have broad implications in the control of sleep in humans.

The NIH Record

The NIH Record, founded in 1949, is the biweekly newsletter for employees of the National Institutes of Health.

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Associate Editor: Carla Garnett
Carla.Garnett@nih.gov

Staff Writers:

Eric Bock
Eric.Bock@nih.gov

Dana Talesnik
Dana.Talesnik@nih.gov

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