According to recent Wednesday Afternoon Lecture Series guest Dr. Brigitte Kieffer, researchers are closer than ever to understanding, witnessing, mimicking and perhaps predicting opioids’ work within the gray matter.
Using a cutting-edge NIH genomic center, a sophisticated microbiology lab and cross-disciplinary collaboration, experts at NIH were able to identify the source of a decade-long outbreak of rather uncommon hospital-acquired Sphingomonas koreensis infections, said NHGRI's Dr. Sean Conlan.
A therapy designed to prevent blindness in people with the inherited neurodegenerative disorder spinocerebellar ataxia type 7 (SCA-7) is nearing the launch pad for testing in clinical trials, said Dr. Albert La Spada, director of the Duke University Center for Neurodegeneration & Neurotherapeutics.
On the Cover
Cells forming bubbles. On the right, two cells (greenish yellow) are in the process of forming bubbles, or plasma membrane vesicles (PMVs). During the blebbing process, a cell’s membrane temporarily disassociates from its underlying cytoskeleton, forming a tiny pouch that, over the course of about 30 minutes, is “inflated” with a mix of proteins and lipids from inside the cell. After the PMVs are fully filled, these bubble-like structures are pinched off and released like those seen in the background.
Photo: Chi Zhao, David Busch, Connor Vershel & Jeanne Stachowiak, University of Texas at Austin