NIH scientists successfully reduced the severity of late-onset Tay-Sachs (LOTS) disease in human cell cultures and a mouse model using a novel gene-editing treatment. LOTS is a rare form of Tay-Sachs disease, with signs and symptoms such as muscle weakness, loss of coordination, muscle spasms and sometimes loss of mental function beginning in late childhood to adulthood.

A scientific team supported in part by NIH has developed a new, ultra-high-resolution brain imaging system that can reconstruct microscopic brain structures that are disrupted in neurological and neuropsychiatric brain disorders. The new system is a significant advance over conventional magnetic resonance imaging (MRI) scanners that cannot visualize these tiny but clinically important structures.