NIAID has launched a phase 1 clinical trial evaluating three experimental HIV vaccines based on a messenger RNA (mRNA) platform—a technology used in several approved Covid-19 vaccines.

Electronic cigarette use—also called vaping—has been on the rise.

Calorie restriction—reducing food intake without causing malnutrition—can yield health benefits that include improved metabolism and delayed onset of age-associated diseases.

Scientists from two independent research teams have discovered how the mislocalization of a protein, known as TDP-43, alters the genetic instructions for UNC13A, providing a possible therapeutic target that could have implications in treating amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and other forms of dementia.

After studying blood samples from 244 patients hospitalized for Covid-19, a group of researchers, including NIH investigators, identified “rogue antibodies” that correlate with severe illness and may help explain mechanisms associated with severe blood clotting.

A recent NIDCD study mapped the brain during speech planning. The findings may lead to a better understanding of speech disorders such as stuttering.

NIH researchers have found unique expression profiles in 50 genes that help identify rare anti-tumor lymphocytes that can infiltrate and help defeat metastatic solid epithelial tumors.

A woman with HIV who received a cord blood stem cell transplant to treat acute myeloid leukemia has had no detectable levels of HIV for 14 months despite cessation of antiretroviral therapy (ART). The woman is the third known case of HIV remission following a stem cell transplant.

Using an experimental drug, researchers suppressed a mutated amyotrophic lateral sclerosis (ALS) gene. Studies in mice demonstrate the therapy shows potential in treating rare, aggressive forms of ALS caused by mutations in the fused in sarcoma (FUS) gene.

Survey data found that supportive relationships with family and friends and healthy behaviors—such as engaging in physical activity and better sleep—appeared to shield against the harmful effects of the pandemic on adolescents’ mental health.