NIH researchers have demonstrated in mice that gene therapy may be the best method for correcting the single faulty gene that causes Niemann-Pick disease, type C1 (NPC1).

Researchers at NIH have developed a new, less invasive way to perform transcatheter aortic valve replacement (TAVR), a procedure widely used to treat aortic valve stenosis, a lethal heart condition.

Researchers investigating how temperament shapes adult life-course outcomes have found that behavioral inhibition in infancy predicts a reserved, introverted personality at age 26.

African Americans with severe sleep apnea and other adverse sleep patterns are much more likely to have high blood glucose levels—a risk factor for diabetes—than those without these patterns, according to a new NHLBI study.

Hospitalized patients with advanced COVID-19 and lung involvement who received remdesivir recovered faster than similar patients who received placebo, according to a preliminary data analysis from a randomized, controlled trial involving 1,063 patients, which began on Feb. 21.

Invasive procedures such as bypass surgery and stenting—commonly used to treat blocked arteries—are no better at reducing the risk for heart attack and death in patients with stable ischemic heart disease than medication and lifestyle changes alone.

In a new study, higher daily step counts were associated with lower mortality risk from all causes.

According to a recent analysis of data from two major eye disease studies, adherence to the Mediterranean diet—high in vegetables, whole grains, fish and olive oil—correlates with higher cognitive function.

The antiretroviral drugs dolutegravir and emtricitabine/tenofovir alafenamide fumarate (DTG+FTC/TAF) may comprise the safest and most effective HIV treatment regimen currently available during pregnancy, researchers announced.

Scientists at NIH and other institutions have devised a new strategy to stop tumors from developing the new blood vessels they need to grow.