Defying the odds, an individual at high risk for early-onset Alzheimer’s disease remained dementia-free for many years beyond what was anticipated. A study funded in part by NIA led researchers to suggest that a gene variant may be the key, perhaps providing a new direction toward developing a treatment.

Scientists funded by NIH have developed an investigational vaccine that protected cynomolgus macaques against four types of hemorrhagic fever viruses endemic to overlapping regions in Africa.

New preclinical research reported in animal models shows that exposure to compounds found in marijuana called cannabinoids (CBs), which includes cannabidiol (CBD) and tetrahydrocannabinol (THC), during early pregnancy can cause malformations in the developing embryo.

Results from a large, national clinical trial show that corneal donor tissue can be safely stored for 11 days without negatively impacting the success of transplantation surgery to restore vision in people with diseases of the cornea.

Obesity during pregnancy—independent of its health consequences such as diabetes—may account for the higher risk of giving birth to an atypically large infant.

A study comparing the effectiveness of two pharmacologically distinct medications used to treat opioid use disorder—a buprenorphine/naloxone combination and an extended release naltrexone formulation—shows similar outcomes once medication treatment is initiated.

Exposure to common air pollutants, such as ozone and fine particles, may increase the risk of early pregnancy loss.

In an early phase clinical trial of a new oral drug, selumetinib, children with the common genetic disorder neurofibromatosis type 1 (NF1) and plexiform neurofibromas, tumors of the peripheral nerves, tolerated selumetinib and, in most cases, responded to it with tumor shrinkage.

Hearing loss among U.S. adults ages 20 to 69 has declined over the last decade, even as the number of older Americans continues to grow.These findings also confirm that hearing loss is strongly associated with age and other demographic factors such as sex, race/ethnicity and education.

Researchers at NIH have found that the blood protein tau could be an important new clinical biomarker to better identify athletes who need more recovery time before safely returning to play after a sports-related concussion.