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NIH Record - 75th Anniversary - National Institutes of Health

Aspirin May Help Increase Pregnancy Chances in Women With High Inflammation

Bottle of aspirin tablets spilling onto surface

A daily low dose of aspirin may help some women successfully conceive and carry a pregnancy to term.

A daily low dose of aspirin may help a subgroup of women, those who have previously lost a pregnancy, to successfully conceive and carry a pregnancy to term, according to an analysis by NIH researchers. The women who benefited from the aspirin treatment had high levels of C-reactive protein (CRP), a substance in the blood indicating system-wide inflammation, which aspirin is thought to counteract. The study appears in the Journal of Clinical Endocrinology and Metabolism.

Researchers at NICHD analyzed data originally obtained from the Effects of Aspirin in Gestation and Reproduction trial. The trial sought to determine if daily low-dose aspirin could prevent subsequent pregnancy loss among women who had one or two prior losses.

For the current study, researchers classified the women into 3 groups: low CRP (below .70 mg per liter of blood), mid CRP (from .70 to 1.95) and high CRP (at or above 1.95). Women within each group received either daily low-dose aspirin or a placebo. In their analysis, researchers found no significant differences in birth rates between those receiving aspirin and those receiving placebo in both the low-CRP and mid-CRP groups. For the high-CRP group, those taking the placebo had the lowest rate of live birth at 44 percent, while those taking daily aspirin had a live-birth rate of 59 percent. Aspirin also appeared to reduce CRP levels in the high-CRP group. 

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