Palsson to Discuss iModulons
NIH’s Office of Data Science Strategy hosts a seminar series to highlight exemplars of data sharing and reuse on the second Friday of each month. The next seminar will take place on May 9 at noon.
Dr. Bernhard Palsson, director and principal investigator in the Departments of Bioengineering and Pediatrics, University of California, San Diego, will discuss iModulons.
The first microbial genome sequences appeared in the mid to late 1990s. By the late 2000s, the cost of DNA sequencing dropped massively, leading to rapidly expanding databases of microbial genome sequences and microbial transcriptomes. These data sets could be knowledge-enriched and decomposed into coherently functioning sets of genes using machine learning methods.
Analysis of large biological data sets can take place at four levels. This talk will focus on progress at level 2 with transcriptomes. Large compendia of high-quality RNAseq profiles can now be decomposed using Independent Component Analysis (ICA). ICA identifies independently modulated sets of genes, called iModulons.
This talk will show the uses of iModulons for metabolic engineering and bioprocess development including cross-species transfer of iModulons, media composition, expression of heterologous genes, and y-gene discovery.
The series is open to the public. Registration is required. To learn more and register, see: bit.ly/NIHDataSeminars. Individuals who need interpretating services and/or other reasonable accommodations to participate in this event should contact Allison Hurst (ahurst@scgcorp.com) at 301-670-4990, at least three business days in advance. A recording of the seminar will be posted after the event.