NIH Record - National Institutes of Health

Scientists Discover New Molecular Pathway Shared by Two Neurodegenerative Disorders

Scientists from two independent research teams have discovered how the mislocalization of a protein, known as TDP-43, alters the genetic instructions for UNC13A, providing a possible therapeutic target that could have implications in treating amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and other forms of dementia.

Silencing a Faulty Gene May Uncover Clues to Rare Forms of ALS

Using an experimental drug, researchers suppressed a mutated amyotrophic lateral sclerosis (ALS) gene. Studies in mice demonstrate the therapy shows potential in treating rare, aggressive forms of ALS caused by mutations in the fused in sarcoma (FUS) gene.

Signs of Mental Health Resilience in Youth During Pandemic

Survey data found that supportive relationships with family and friends and healthy behaviors—such as engaging in physical activity and better sleep—appeared to shield against the harmful effects of the pandemic on adolescents’ mental health.

The NIH Record

The NIH Record, founded in 1949, is the biweekly newsletter for employees of the National Institutes of Health.

Published 25 times each year, it comes out on payday Fridays.

Assistant Editor: Eric Bock (link sends e-mail)

Staff Writer: Amber Snyder (link sends e-mail)