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NIH Record - 75th Anniversary - National Institutes of Health

Scientists Discover New Molecular Pathway Shared by Two Neurodegenerative Disorders

Scientists from two independent research teams have discovered how the mislocalization of a protein, known as TDP-43, alters the genetic instructions for UNC13A, providing a possible therapeutic target that could have implications in treating amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and other forms of dementia.

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