On the Cover
iPSC colonies captured using phase contrast microscopy. Derived from human umbilical cord blood, these iPSC colonies will give rise to regulatory B cells (Bregs) that suppress CNS autoimmune diseases. This research, conducted in the lab of NEI senior investigator Dr. Charles E. Egwuagu, aims to generate human immune organoids that produce a hypoimmunogenic “off-the-shelf” source for Bregs for cell-based therapy.
VIJAY NAGARAJAN / NEI