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NIH Record - National Institutes of Health

Scientists Develop Infection Model for Tick-Borne Flaviviruses

An adult and nymphal tick next to a coin

Ixodes scapularis tick, adult and nymphal forms

Photo: NIAID

NIH scientists have filled a research gap by developing a laboratory model to study ticks that transmit flaviviruses, such as Powassan virus. Powassan virus was implicated in the death of a New York man earlier this year. The unusual model involves culturing organs taken from Ixodes scapularis ticks and then infecting those organ cultures with flaviviruses, according to researchers at Rocky Mountain Laboratories, part of NIAID. The researchers say the culture model, described in mBio, will greatly increase knowledge about how flaviviruses infect ticks and could become a tool to evaluate medical countermeasures against tick-borne viruses.

Flaviviruses are the cause of diseases spread by mosquitoes (e.g., dengue fever and West Nile fever) and by ticks (e.g., Powassan virus disease and tick-borne encephalitis). Powassan virus and the closely related deer tick virus are the only flaviviruses known to be spread by ticks in North America. 

The NIAID scientists developed their model by dissecting three tick organs—the midgut, salivary glands and nervous tissue—and then culturing flaviviruses in those organs, evaluating their viability over several days. They found that Powassan virus and the related Langat virus could infect and spread in salivary glands and midgut. Langat virus is found typically in Southeast Asia and is an ideal model virus for study because it causes only rare, mild infections in people.

The NIH Record

The NIH Record, founded in 1949, is the biweekly newsletter for employees of the National Institutes of Health.

Published 25 times each year, it comes out on payday Fridays.

Associate Editor: Carla Garnett
Carla.Garnett@nih.gov

Staff Writers:

Eric Bock
Eric.Bock@nih.gov

Dana Talesnik
Dana.Talesnik@nih.gov

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