NIH Record - National Institutes of Health

‘Cryo-EM revolution’

Subramaniam To Give Mider Lecture, Apr. 11

Dr. Sriram Subramaniam
Dr. Sriram Subramaniam

NCI’s Dr. Sriram Subramaniam will present the annual G. Burroughs Mider Lecture as part of the NIH Director’s Wednesday Afternoon Lecture Series. His talk, “The cryo-EM revolution,” will be held Wednesday, Apr. 11 at 3 p.m. in Masur Auditorium, Bldg. 10.

Subramaniam’s work is focused on the development of advanced technologies for imaging macromolecular assemblies using 3-D electron microscopy and their application to address fundamental problems in infectious disease, cancer and neuroscience.

Research in his lab over the last decade has been guided by the vision that emerging tools in 3-D electron microscopy hold great promise for imaging cells, viruses and protein complexes at high resolution in their native states, thus bridging a major gap in structural biology.

In his talk, he will review examples of recent progress ranging from determination of protein structures at atomic resolution to imaging viruses, cells and tissue at nanometer resolution.

Subramaniam received his undergraduate training in engineering and science at the Indian Institute of Technology in Kanpur, India, a Ph.D. in physical chemistry from Stanford University and completed postdoctoral training in the departments of chemistry and biology at M.I.T. He is currently a senior investigator and founding director of both the Center for Molecular Microscopy and the National Cryo-EM Facility at NCI. He also holds visiting faculty appointments at Johns Hopkins University School of Medicine and the Institute for Advanced Computer Studies at the University of Maryland.

The Mider lecture, established in 1968, recognizes an NIH intramural scientist’s outstanding contributions to biomedical research and honors G. Burroughs Mider, the first director of NIH laboratories and clinics.

For lecture information and reasonable accommodation, contact Jacqueline Roberts, (301) 594-6747 or

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