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NIH Record - 75th Anniversary - National Institutes of Health

Hopeful News for Women Who Take Antiseizure Medication During Pregnancy

Smiling toddler boy is handed a flower by adult woman whose back is toward the camera.

New findings suggest there is no difference in cognitive outcomes at age 2 among children of healthy women and children of women with epilepsy who took antiseizure medication during pregnancy.

Photo: Paul Bradbury/OJO Images/Getty

New findings suggest there is no difference in cognitive outcomes at age 2 among children of healthy women and children of women with epilepsy who took antiseizure medication during pregnancy. The findings are part of the large, long-term research project, Maternal Outcomes and Neurodevelopmental Effects of Antiepileptic Drugs, funded by NINDS. The latest results were published in JAMA Neurology.

This study reports findings from 382 children (292 children born to women with epilepsy and 90 born to healthy women) who were assessed for language development at age 2. The researchers also compared developmental scores with third trimester blood levels of antiseizure medication in these children. 

Results suggest that children born to healthy women and those born to women with epilepsy do not show significant differences in language development scores at age 2, and language development was not linked to third trimester blood levels of epilepsy medications. Most women with epilepsy in the study were taking lamotrigine and/or levetiracetam.

However, the study did find that those children born to mothers with the highest levels of antiseizure medication in the blood during the third trimester did have somewhat lower scores on tests in the motor and general adaptive domains, which refer to skills related to self-care, such as feeding.

The children in this study will continue to be followed and will participate in additional cognitive tests through age 6. Results so far indicate that controlling epilepsy with these medications during pregnancy may be safe for babies.

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