NIH Record - National Institutes of Health

Series Celebrates 25 Years

Holland To Give 2022 Astute Clinician Lecture

Dr. Steven Holland
Dr. Steven Holland

NIH distinguished investigator Dr. Steven Holland will give the Astute Clinician Lecture as part of the NIH Director’s Wednesday Afternoon Lecture Series on Nov. 2 from 2 to 3 p.m. via NIH videocast. He will present “Anticytokine Autoantibodies: Causes, Concomitants and Complications of Infectious Diseases.” Holland’s lecture marks the 25th anniversary of the Astute Clinician Lecture Series.

Holland is NIAID scientific director and chief of the immunopathogenesis section, which uses a bench-to-bedside model for a fully integrated approach to infectious disease—incorporating the molecular genetics of the host and the pathogen as well as mechanisms of pathogenesis, together with clinical appreciation and investigation—to gain new insights into both mechanisms of action and avenues of therapy.

Holland earned his M.D. from Johns Hopkins University, where he remained for his internal medicine residency, chief residency, and fellowship in infectious diseases. He came to the NIAID as a National Research Council fellow in 1989 in the Laboratory of Molecular Microbiology, working on transcriptional regulation of HIV. 

In 1992 he joined the newly formed Laboratory of Host Defenses, shifting his research to the host side, with a focus on phagocyte defects and their associated infections. His work centered on the pathogenesis and management of chronic granulomatous disease, as well as other congenital immune defects affecting phagocytes, including those predisposing to mycobacterial diseases. 

Holland became NIAID scientific director in 2016. 

The Astute Clinician Lecture was established in 1998 with a gift from the late Dr. Robert W. Miller and his wife, Haruko. The talk honors U.S. scientists who have observed unusual clinical occurrences and, by investigating them, have opened an important new avenue of research. Learn more at

The lecture will be held in Lipsett Amphitheater, Bldg. 10, and viewable online live via NIH videocast. To attend in person, email so that the number of attendees can be monitored for Covid-19 safety reasons.

More information about WALS is posted at Sign language interpreting services are available upon request. For interpreting services or other reasonable accommodation, email or call (301) 594-6747.

The NIH Record

The NIH Record, founded in 1949, is the biweekly newsletter for employees of the National Institutes of Health.

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Staff Writer: Amber Snyder (link sends e-mail)