Using 3-D models of ovarian cancer tumors, scientists found differences in gene activity based on where a cell is in a tumor, demonstrating how a cell’s location and environment in a cancerous tumor can influence which genes are active and the cell’s role in the cancer’s biology.

An NIH-supported trial marks the first step in developing new approach to treat myasthenia gravis.

Researchers found widespread screening of newborns for a deadly disease called severe combined immunodeficiency (SCID), followed by early treatment boosted the five-year survival rate of children with the disorder from 73% before the advent of screening to 87% since.

A recent follow-up analysis of data from an international, NIH-funded clinical trial suggests daily low-dose aspirin increases the risk of anemia in people ages 65 years and older by approximately 20%

Researchers at NIH and their colleagues have identified genomic variants that cause a rare and severe inflammatory skin disorder, known as disabling pansclerotic morphea, and have found a potential treatment.

Genetic differences between people can cause or alter the severity of various diseases and influence the effectiveness of treatments. Scientists identify such genetic variants by comparing an individual’s genome sequence to a standard, which is known as a reference genome. An NIH-funded consortium has developed a reference “pangenome” that represents more human genetic diversity. The pangenome resembles a transit map, with different lines representing each component genome.

NCI has launched a large precision medicine cancer initiative to test the effectiveness of treating adults and children with new drug combinations that target specific tumor alterations. Known as the Combination Therapy Platform Trial with Molecular Analysis for Therapy Choice (ComboMATCH), the initiative is the largest of its kind to test combinations of cancer drugs guided by tumor biology.

A study from NIH shows that new cases of chronic pain occur more often among U.S. adults than new cases of several other common conditions, including diabetes, depression and high blood pressure.

A groundbreaking study provides national and state-level estimates of the economic burden of health disparities by race, ethnicity and educational levels. New research shows that the economic burden of health disparities in the United States remains unacceptably high.

Vigorous exercise does not appear to increase the risk of death or life-threatening arrhythmia for people with hypertrophic cardiomyopathy (HCM), according to a study supported by NIH.