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NIH Record - National Institutes of Health

Study of ‘Exceptional Responders’ Yields Clues to Cancer, Potential Treatments

In a comprehensive analysis of patients with cancer who had exceptional responses to therapy, researchers have identified molecular changes in the patients’ tumors that may explain some of the exceptional responses. The results demonstrate that genomic characterizations of cancer can uncover genetic alterations that may contribute to unexpected and long-lasting responses to treatment.

NIH Research Contributed to First FDA-Approved Treatment for Progeria

Nearly two decades of NIH research helped lead to the first FDA-approved treatment for progeria, a rare and fatal pediatric disease, characterized by dramatic, rapid aging beginning in childhood. The new treatment was made possible thanks in part to the work of NHGRI researchers, led by NIH director and NHGRI senior investigator Dr. Francis Collins.

Gut Trains Immune System to Protect Brain

The membranes surrounding our brains are in a never-ending battle against deadly infections, as germs constantly try to elude watchful immune cells and sneak past a special protective barrier called the meninges. In a study involving mice and human autopsy tissue, researchers at NIH and Cambridge University have shown that some of these immune cells are trained to fight these infections by first spending time in the gut.

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