On the Cover
These images, produced using fluorescence microscopy, show artery sections of a mouse model used in a recent NHLBI-supported study of atherosclerosis, a source of heart disease. In the study, researchers found that using a mouse model expressing a known cancer mutation accelerated cellular changes and worsened atherosclerosis. They also demonstrated that an anticancer drug, niraparib, shows promise for both preventing and treating atherosclerotic cardiovascular disease. The findings could help pave the way for new treatments for heart disease.
MUREDACH REILLY, COLUMBIA UNIVERSITY AND HUIZE PAN, VANDERBILT UNIVERSITY MEDICAL CENTER. ILLUSTRATION BY JEAN NAUMANN, NHLBI