Core Centers for Musculoskeletal Disorders
Two new Core Centers for Musculoskeletal Disorders have just been funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases. The first, at the Hospital for Special Surgery in New York City, will concentrate on research studies of skeletal integrity, which encompasses biological, chemical and mechanical influences on bones. The second, at Yale University, will focus on basic bone biology and bone diseases.
The New York center, under the leadership of Dr. Timothy M. Wright, will bring together two groups of investigators to examine the relationship between skeletal composition, structure and function. These factors control skeletal integrity and are important at all levels of skeletal organization, from individual molecules to the entire skeletal system. The center will provide its scientists with the tools and training to study the chemical composition, morphology and mechanical properties of bone. It will conduct its activities in three research areas: analytical micro-scopy, infrared imaging and mechanical testing.
Dr. Karl L. Insogna will lead a team of 26 investigators at the Yale Core Center for Musculoskeletal Disorders, who share the goal of using animal models to better understand the basic mechanisms of musculoskeletal disease. The center has created three core facilities to support their work: a molecular core to carry out animal genetic expression studies relevant to human musculoskeletal disease; a physiology core to support biochemical and other analyses of the skeletons of experimental animals; and a cell core to culture bone-building and bone-destroying cells for animal studies.
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