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NIH Record

Baron To Deliver Kreshover Lecture

Dr. Roland Baron, professor of orthopedics and cell biology at Yale University School of Medicine, will deliver the 1997 NIDR Seymour J. Kreshover Lecture on Wednesday, June 11, at 3 p.m. in Lister Hill Auditorium, Bldg. 38A.

Dr. Roland Baron

A world-renowned scientist in bone research, Baron will discuss the "Molecular Mechanisms of Bone Resorption." His special area of interest is osteoclast cell biology, and the intracellular signaling pathways that are required by osteoclasts to attach to, and destroy bone. These studies are of great importance in finding ways to regulate osteoclastic bone resorption to prevent loss of bone in a variety of diseases including osteoporosis, and bone loss in association with metastatic bone disease.

Baron's early work led to generation of the current hypothesis of how osteoclasts degrade both the mineral and protein components of bone matrix. An osteoclast has the unique ability to set up a special compartment that contains lysosomal enzymes outside of the cell. Usually this lysosomal compartment is found only inside of a cell. Osteoclasts not only secrete enzymes necessary to degrade bone matrix proteins, but they also secrete ions that lower the pH level of this sealed extracellular compartment to dissolve the mineral and enhance the activity of the lysosomal enzymes that are secreted there.

Baron, a long-time NIDR grantee, also is director of biological research in the orthopaedics department at Yale and head of research in therapeutic area bone diseases at Hoechst Marion Roussel Pharmaceuticals. He is editor-in-chief of Bone and an editor of the Journal of Cellular Physiology.

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