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MIT's Lodish Gives Director's Lecture

Dr. Harvey F. Lodish, professor of biology at the Massachusetts Institute of Technology, will deliver the NIH Director's Lecture on Wednesday, Sept. 16 at 3 p.m. in Masur Auditorium, Bldg. 10. He will speak on the "Erythropoietin Receptor and the Control of Red Cell Production."

Initially, Lodish's work focused on translational control of protein synthesis and on regulation of gene expression during differentiation of the cellular slime mold. He was first to define the biosynthesis and maturation of the vesicular stomatitis virus glycoprotein, identified intracellular organelles that mediate recycling of asialoglycoprotein and transferrin receptors, and clarified the role of pH changes in iron delivery to cells and transferrin receptor recycling.

Dr. Harvey F. Lodish

More recently, his group has elucidated the steps in folding and oligomerization of several proteins within the endoplasmic reticulum, shown that exit of newly made proteins from this organelle requires that they be properly folded, and developed probes for measurement of the redox state within the endoplasmic reticulum. His group has cloned and sequenced mRNAs encoding the erythrocyte glucose transporter, the anion exchange protein, a transporter for free fatty acids, the human asialoglycoprotein receptors, the calcitonin and endothelial receptors, intestinal sucrose-isomaltase, the murine erythropoietin receptor, and two subunits of the TGF receptor. These have been used to define the structure and synthesis of the proteins, to identify and sequence related genes that encode proteins of related physiological function, and, most recently, to elucidate the modes of signal transduction of the TGF and erythropoietin receptors and their roles in tumorigenesis.

Lodish received his A.B. degree in chemistry and mathematics, summa cum laude, from Kenyon College in 1962, and his Ph.D. degree in genetics with Dr. Norton Zinder from Rockefeller University in 1966. Following 2 years of postdoctoral research at the MRC Laboratory of Molecular Biology with Drs. Sydney Brenner and Francis Crick, he joined the faculty of MIT's department of biology. He was promoted to professor in 1976, and in 1983 was appointed member of the new Whitehead Institute.

Lodish is a member of the National Academy of Sciences and a fellow of the American Association for the Advancement of Science. He is on the editorial board of the Proceedings of the National Academy of Sciences and on the board of reviewing editors of Science. He is an author of the textbook Molecular Cell Biology, now in its third edition.

The talk marks the return of the Wednesday Afternoon Lecture series in Masur Auditorium. For more information or reasonable accommodation, contact Hilda Madine, 594-5595.

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