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Vol. LIX, No. 22
November 2, 2007

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Astute Clinician Lecture Addresses Coronary Artery Disease

  Dr. Barry Coller  
  Dr. Barry Coller  
“From the Rivers of Babylon to the Coronary Blood Stream” will be the topic of the 2007 Astute Clinician Lecture on Wednesday, Nov. 7 at 3 p.m. in Masur Auditorium, Bldg. 10.

The speaker will be Dr. Barry Coller, David Rockefeller professor of medicine, head of the laboratory of blood and vascular biology and physician-in-chief of Rockefeller University Hospital. He is also vice president for medical affairs at Rockefeller University.

A graduate of Columbia College and New York University School of Medicine, Coller studies hemostasis, thrombosis and platelet physiology. He and his colleagues examine patients with the platelet disorder Glanzmann thrombasthenia, which affects about one person in a million and involves lifelong excessive bleeding. Their clinical observations helped them develop therapeutic and diagnostic strategies for coronary artery disease, one of the most common causes of death in the world.

Coller studied a defect in these patients’ platelets that affects the platelets’ ability to aggregate. Based on this knowledge, his laboratory developed an antibody that blocks the ability of normal platelets to aggregate. A derivative of that antibody (abciximab) received FDA approval in 1994 and has been used to treat more than 2 million patients worldwide to prevent complications of coronary interventions such as angioplasty and stent insertion. Treatment with abciximab prevents clots from forming in stents used to open the diseased arteries in patients with heart attacks. A recipient or co-recipient of 13 U.S. patents, Coller also developed an assay to assess platelet function and has received FDA approval to monitor antiplatelet therapy with aspirin and other agents.

Coller has received numerous awards, including the American Society of Hematology’s Henry M. Stratton Medal and the Robert J. and Claire Pasarow Foundation Award for Cardiovascular Research in 2005.

Coller is a member of the Association of American Physicians, the Institute of Medicine of the National Academies and the National Academy of Sciences. He has served as a member of NHLBI’s board of extramural advisors and co-chair of NIH’s advisory board for clinical research. He also worked at the Clinical Center from 1972 to 1976 in the clinical pathology department.

The Astute Clinician Lecture was established through a gift from the late Dr. Robert W. Miller and his wife, Haruko. It honors a U.S. scientist who has observed an unusual clinical occurrence, and by investigating it, has opened a new avenue of research. For information and accommodations, contact Gloria Hairston, (301) 594-6747. NIH Record Icon

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