Dr. Charles Dinarello
Dr. Charles Dinarello, who purified and cloned interleukin-1 beta (IL-1 beta), once known as the fever molecule, will deliver the 2010 Kinyoun
Lecture on Thursday, Nov. 18 at 3 p.m. in Lipsett Amphitheater, Bldg. 10. Dinarello is professor of medicine and immunology at the University of Colorado School of Medicine and a former investigator in NIAID’s Laboratory of Clinical Investigation.
His talk, titled “Treating Auto-inflammatory
Diseases with Interleukin-1 beta Blockade,” will include an overview of autoinflammatory diseases such as type 2 diabetes mellitus and gout and describe differences between these and autoimmune diseases. He also will discuss treatment of inflammatory diseases using IL-1 beta blocking agents.
Dinarello is considered one of the founding fathers of cytokine biology. His work with IL-1 helped to establish the significance of cytokines in inflammatory diseases. His recognition of the importance of IL-1 in inflammatory diseases
led to the development of therapies that inhibit IL-1 and thereby reduce disease severity. These therapies include those based on the IL-1 receptor antagonist, monoclonal antibodies and soluble receptors.
Dinarello received his medical degree in 1969 from Yale University. He came to work in NIAID’s Laboratory of Clinical Investigation in 1971, alongside Dr. Sheldon Wolff, becoming
a senior investigator in 1975. Dinarello left NIAID in 1977 to join the faculty at Tufts University,
a position he held until 1996, when he went to the University of Colorado.
He has received numerous awards for his contributions
to the cytokine biology field. Most recently, he received the Albany Medical Center
Prize in Medicine, the Crafoord Prize from the Royal Swedish Academy of Sciences, the Paul Ehrlich Prize and the Novartis Prize in Immunology.
Dinarello is a member of the National Academy
of Sciences. He currently serves on the editorial board of several scientific journals including the Proceedings of the National Academy of Sciences and the board of governors of the Weizmann Institute of Science and Ben-Gurion University
The Kinyoun Lecture honors Dr. Joseph J. Kinyoun, who in 1887 founded the Laboratory of Hygiene, forerunner of NIH, to study infectious diseases. NIAID sponsors the Kinyoun lecture series, which highlights advances in the understanding
of infection and immunity .